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. 2021 Apr 15;21:216. doi: 10.1186/s12935-021-01914-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The combination of trichostatin A (TSA) and JQ1 synergistically inhibited the growth of osimertinib sensitive and resistant H1975 cells. a Osimertinib resistant (H1975-OR) and osimertinib sensitive parental (H1975-P) cells were treated with TSA (2 μmol/L), JQ1 (10 μmol/L), or their combination for 24 h, and then subjected to western blot analysis. b Cells were treated with TSA, JQ1, or their combination in different concentrations as indicated for 3 days and then subjected to sulforhodamine B (SRB) assays, followed by combination index assays using CompuSyn software. Points, mean; bars, SD. c–e, The tumor size (c), tumor weight (d), and body weight (e) of the xenograft mouse model are presented. The vehicle control, TSA (0.5 mg/kg/d), JQ1 (100 mg/kg/d), or their combination was administered for 21 day. In C: columns, mean. In D: points, individual tumor weight; horizontal line, mean tumor weight. In E Points, mean; bars, SD; *, P < 0.05 vs. control; #, P < 0.05 vs. TSA; $, P < 0.05 vs. JQ1