${\mathit{RNA}}_i^{\left(k\right)}>{\mathit{RNA}}_j^{\left(k\right)}$	${\mathit{RNA}}_i^{\left(k\right)}<{\mathit{RNA}}_j^{\left(k\right)}$
Normal	$\mathrm{a}=\frac{1}{2}\sum _{k=1}^n\left(r_{\mathit{ij}}^{\left(k\right)}+1\right)\times \left(1-Y^{\left(k\right)}\right)$	$\mathrm{b}=\frac{1}{2}\sum _{k=1}^n\left(1-r_{\mathit{ij}}^{\left(k\right)}\right)\times \left(1-Y^{\left(k\right)}\right)$
Sepsis	$\mathrm{c}=\frac{1}{2}\sum _{k=1}^n\left(r_{\mathit{ij}}^{\left(k\right)}+1\right)\times Y^{\left(n\right)}$	$\mathrm{d}=\frac{1}{2}\sum _{k=1}^n\left(1-r_{\mathit{ij}}^{\left(k\right)}\right)\times Y^{\left(n\right)}$