Fig. 1.

Schematic depicting the involvement of extrinsic and intrinsic apoptosis pathways in SHK mediated cell death on PEL cells. The extrinsic pathway is triggered by kinases (p38, JNK, ERK) mediated caspase-3 activation. Additionally, caspase-8 could also activate caspase-3 independent of the kinases mediated activation and this route is also considered as the extrinsic pathway of activation. This pathway is primarily controlled by a multiprotein complex called DISK downstream of Fas receptor. Mitochondrial membrane potential perturbation leads to the intrinsic pathway activation. This pathway activates caspase-9 and caspase-3 inducing apoptosis.