Figure 1. . Oxycodone primarily gets metabolized to noroxycodone and oxymorphone and later to noroxymorphone.

The drug and it metabolites can also undergo glucuronidation before elimination. Oxycodol, noroxycodol and oxymorphol are reductive metabolites of oxycodone, noroxycodone and oxymorphone respectively, with each of them having two stereoisomers (α and β). % mentioned next to an arrow represents the percentage of drug eliminated in that specific pathway and % mentioned in the boxes represent the percentage of eliminated metabolite compared with the parent drug. Pathways with no % mentioned have very minimal contribution to the drug’s elimination.

CYP: Cytochrome P450; UGT: Uridine 5′-diphospho-glucuronosyltransferase or UDP-glucuronosyltransferase.