Table 5.
Levels of AST, ALT, ALB, TBIL, ALP, GGT, CREAT, and BUN in the two groups at baseline, day 1, and weeks 1, 2, 4, 8, and 12
| AST | ALT | ALB | TBIL | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rituximab | MSC | P | Rituximab | MSC | P | Rituximab | MSC | P | Rituximab | MSC | P | |
| Baseline | 97.00 (53.00–180.00) | 69.00 (21.00–111.00) | 0.217 | 99 (18.00–233.00) | 30 (9.00–94.00) | 0.171 | 34.20 (33.20–36.20) | 32.20 (30.80–35.80) | 0.773 | 590.07 (202.35–702.68) | 420.73 (38.45–541.73) | 0.116 |
| Day 1 | 794.00 (342.00–1032.00) | 782.00 (308.00–2120.00) | 0.748 | 355.00 (148.00–852.00) | 380.00 (259.00–935.00) | 0.652 | 35.10 (31.50–37.00) | 33.90 (30.90–35.40) | 0.411 | 163.07 (92.93–316.96) | 119.00 (39.70–167.06) | 0.193 |
| Week1 | 45.00 (20.00–88.00) | 34.00 (24.00–34.00) | 0.898 | 106.00 (24.00–217.00) | 79.00 (58.00–219.00) | 0.652 | 35.50 (31.90–40.40) | 34.30 (31.10–36.30) | 0.263 | 48.69 (39.30–158.60) | 41.64 (15.07–86.92) | 0.365 |
| Week2 | 33.00 (15.25–60.25) | 18.50 (12.50–37.25) | 0.387 | 67.50 (19.50–176.25) | 36.00 (17.50–116.00) | 0.426 | 36.10 (33.40–38.70) | 36.90 (34.73–40.48) | 0.644 | 42.05 (23.73–81.29) | 19.87 (15.04–42.11) | 0.314 |
| Week4 | 38.00 (21.00–124.00) | 28.00 (17.00–36.00) | 0.261 | 49.00 (26.00–158.00) | 28.00 (17.50–55.50) | 0.295 | 39.10 (36.60–42.60) | 45.40 (40.90–47.45) | 0.01* | 20.87 (17.14–56.74) | 18.87 (11.00–28.58) | 0.412 |
| Week8 | 43.00 (19.00–67.00) | 18.00 (14.50–39.00) | 0.112 | 30.00 (16.00–158.00) | 28.00 (15.50–91.50) | 0.766 | 43.20 (37.50–44.50) | 44.20 (41.60–47.50) | 0.152 | 20.07 (12.70–53.24) | 12.80 (8.90–15.51) | 0.112 |
| Week12 | 28.00 (20.00–32.00) | 21.00 (18.00–40.00) | 0.489 | 20.00 (13.00–50.50) | 21.00 (13.50–96.50) | 0.73 | 40.70 (38.85–45.65) | 42.60 (41.85–46.30) | 0.245 | 12.48 (8.42–25.97) | 10.00 (9.45–12.40) | 0.387 |
| Baseline | 99.00 (71.00–116.00) | 99.00 (95.00–124.00) | 0.478 | 51.00 (42.00–75.00) | 49.00 (33.00–77.00) | 1 | 71.00 (56.00–174.00) | 76.00 (45.00–114.00) | 0.748 | 5.35 (3.18–15.44) | 7.73 (5.01–9.16) | 0.699 |
| Day1 | 63.00 (45.00–89.00) | 65.00 (50.00–73.00) | 0.478 | 51.00 (22.00–62.00) | 45.00 (34.00–51.00) | 1 | 105.00 (72.00–183.00) | 92.00 (79.00–201.00) | 1 | 11.79 (9.36–19.33) | 14.28 (13.45–16.18) | 0.519 |
| Week1 | 68.00 (59.00–181.00) | 82.00 (59.00–103.00) | 0.949 | 78.00 (39.00–279.00) | 149.00 (64.00–203.00) | 0.949 | 54.00 (44.00–124.00) | 60.00 (48.00–84.00) | 0.898 | 17.84 (11.15–30.88) | 14.68 (8.19–17.85) | 0.27 |
| Week2 | 99.50 (70.50–135.75) | 67.00 (47.50–95.50) | 0.24 | 103.50 (76.00–215.25) | 61.50 (35.75–139.00) | 0.705 | 68.50 (48.50–112.50) | 49.50 (45.00–56.25) | 0.282 | 14.48 (9.56–21.76) | 10.97 (7.87–17.21) | 0.152 |
| Week4 | 105.00 (75.00–208.00) | 82.00 (64.50–97.50) | 0.112 | 78.00 (30.00–218.00) | 67.00 (36.00–132.00) | 0.656 | 66.00 (47.00–90.00) | 62.00 (58.50–73.00) | 0.656 | 8.78 (6.67–10.48) | 6.40 (5.81–9.89) | 0.503 |
| Week8 | 125.00 (102.00–226.00) | 90.00 (73.00–117.00) | 0.056 | 95.00 (50.00–361.00) | 55.00 (28.50–60.00) | 0.031* | 83.00 (56.00–177.00) | 68.00 (57.50–95.00) | 0.261 | 11.10 (4.32–16.94) | 7.56 (6.56–10.06) | 0.503 |
| Week12 | 86.00 (69.00–111.50) | 87.00 (62.50–130.50) | 1 | 78.00 (42.00–272.00) | 35.00 (21.00–92.50) | 0.094 | 80.00 (73.50–127.00) | 77.00 (62.50–95.00) | 0.436 | 5.80 (5.21–11.12) | 7.70 (6.68–8.32) | 0.077 |
*P < 0.05
Abbreviations: AST aspartate aminotransferase, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, CREAT creatinine, BUN blood urea nitrogen, MSC mesenchymal stem cell