Table 1.
Missense variants that might influence the acquisition or the course of COVID-19.
| Gene name | Protein name/Mim phenotype | Reference SNP ID number | Amino acid change | Variant frequency | GWAS p-value |
|---|---|---|---|---|---|
| ACE | Angiotensin-converting enzyme | rs3730025 | Tyr244Cys | 0.0107 | |
| AHSG | Alpha-2-HS-glycoprotein #203650 |
rs140827890 | Ala164Thr | 0.0114 | 0.05 |
| CD27 | CD27 antigen #615122 | rs25680 | Ala59Thr | 0.1912 | |
| GFAP | Glial fibrillary acidic protein #203450 |
rs59291670 | Asp157Asn | 0.11 | |
| IFI30 | Gamma-interferon-inducible lysosomal thiol reductase | rs11554159 | Arg76Gln | 0.2281 | |
| MBL2 | Mannose-binding protein C #614372 |
rs1800450 | Gly54Asp | 0.141 | |
| rs5030737 | Arg52Cys | 0.0558 | |||
| rs1800451 | Gly57Glu | 0.0318 | |||
| MEFV | Pyrin #134610 #249100 |
rs3743930 | Glu148Gln | 0.0708 | |
| TLR2 | Toll-like receptor 2 #607948 |
rs5743704 | Pro631His | 0.0281 | 0.02 |
| rs5743708 | Arg753Gln | 0.0176 | |||
| TLR3 | Toll-like receptor 3 #609423 |
rs3775291 | Leu412Phe | 0.2789 | 0.03 |
| TMPRSS2 | Transmembrane protease serine 2 | rs12329760 | Val197Met | 0.2452 | 0.01528 |
Table 1: Likely deleterious frequent variants (allele frequency >1%) in genes referable to the term “SARS-CoV*” in the literature. Variant frequency is referred to gnomAD total exome frequency obtained from wAnnovar annotation. For variants covered in the GWAS study, GCST90000255 Fisher p-values are provided.