Table 2.
Twenty-two ORF10 proteins, their corresponding mutations, and predicted effects with chemical property changes.
| Accession ID | Mutations | Type of mutations | PROVEAN scorea | Effect of mutations on structure | RIb | Polarity changes | Charge |
|---|---|---|---|---|---|---|---|
| QNI23218.1 | G2D | Deleterious | −7 | Decrease | 7 | NP to P | Neutral to acidic |
| QIS29991.1 | V6I | Neutral | −1 | Decrease | 7 | NP to NP | Neutral to neutral |
| QLI33453.1 | Y14C | Deleterious | −9 | Decrease | 2 | P to P | Neutral to neutral |
| QNC04532.1 | R20I | Deleterious | −8 | Decrease | 3 | NP to NP | Basic (strongly) to neutral |
| QLA48060.1 | R20K | Deleterious | −3 | Decrease | 8 | NP to P | Basic (strongly) to basic |
| QMT97141.1 | S23F | Deleterious | −6 | Increase | 2 | P to NP | Neutral to neutral |
| QMU93213.1 | R24C | Deleterious | −8 | Decrease | 7 | P to P | Basic (strongly) to neutral |
| QMT54534.1 | R24L | Deleterious | −7 | Decrease | 9 | P to NP | Basic (strongly) to neutral |
| QKU54102.1 | Y26H | Deleterious | −5 | Decrease | 8 | P to P | Neutral to basic (weakly) |
| QNI25281.1 | V30A | Deleterious | −4 | Decrease | 9 | NP to NP | Neutral to neutral |
| QNC49349.1 | V30L | Deleterious | −3 | Decrease | 4 | NP to NP | Neutral to neutral |
| QNA70543.1 | L37F | Deleterious | −4 | Decrease | 7 | NP to NP | Neutral to neutral |
| QKV37245.1 | T38I | Deleterious | −6 | Decrease | 5 | P to NP | Neutral to neutral |
| QKV08176.1 | L37P | Deleterious | −7 | Decrease | 8 | NP to NP | Neutral to neutral |
| QNB17780.1 | F35S | Deleterious | −8 | Decrease | 9 | NP to P | Neutral to neutral |
| QMT94417.1 | D31Y | Deleterious | −9 | Decrease | 6 | P to P | Acidic to neutral |
| QLY88596.1 | A28V | Deleterious | −4 | Decrease | 5 | NP to NP | Neutral to neutral |
| QLG76514.1 | N22T | Deleterious | −6 | Decrease | 1 | P to P | Neutral to neutral |
| QLG99793.1 | I13M | Deleterious | −3 | Decrease | 8 | NP to NP | Neutral to neutral |
| QNG42985.1 | P10S | Deleterious | −8 | Decrease | 8 | NP to P | Neutral to neutral |
| QLJ57416.1 | A8V | Deleterious | −4 | Increase | 3 | NP to NP | Neutral to neutral |
| QNG41574.1 | I4L | Neutral | −2 | Increase | 1 | NP to NP | Neutral to neutral |
a
PROVEAN score: If the PROVEAN score is equal to or below a predefined threshold (e.g., −2.5), the protein variant is predicted to have a “deleterious” effect. If the PROVEAN score is above the threshold, the variant is predicted to have a “neutral” effect.
b
RI: Reliability Index ranges from 0 to 9.