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. 2021 Apr 16;19:140. doi: 10.1186/s12967-021-02785-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Ingenuity Pathway Analysis (IPA), prediction network of the T1DM conditions presented in this study with the upregulation (red) of miR-126-5p, IL-7, TNF-α, VEGF-C, CXCR1, CXCR2 and glucose. Orange signifies predicted activation of a molecule or biological function. Paler orange shades signify a prediction of less activation. Blue signifies inhibition of a molecule or biological function. White represents a molecule or biological function is unchanged. Orange lines represent stimulation, blues lines represent inhibition, the black lines represent a correlation, grey lines represent reciprocal stimulation and inhibition, and purple lines represents simultaneous stimulation and inhibition. Solid un-interrupted lines represent a direct action and dashed interrupted lines represent an indirect action. Alanine aminotransferase (ALT)