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. 2021 Apr 16;22:109. doi: 10.1186/s13059-021-02315-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Coefficient of variation (CV) of TMB. a Technical run-to-run variance of TMB with VAF cutoff above 2.5% was estimated for six panels at different TMB levels. A power-law curve (dashed line) is fitted for each panel. b Technical run-to-run variance of TMB with VAF cutoff above 5%. c The intrinsic CV is plotted with the equation (embedded, see “Methods” for detail) for each panel based on their panel size. The curve (dashed) for size of 1 Mb is also plotted as a reference. d The overall CV is plotted combining technical and intrinsic CV. The solid fitting power-law curve is for TMB (VAF > 2.5%), and the dashed curve is for TMB (VAF > 5%)