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. 2021 Apr 15;19:76. doi: 10.1186/s12915-021-01009-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Epigenomic marks and expression for three key transcription factors. a Isl1 encodes a key pituitary transcription factor that is expressed in both TαT1 (red) and GHF-T1 (blue) cell lines. Data from RNA-Seq, CUT&RUN for active chromatin marks (H3K27Ac and H3K4Me1), open chromatin (ATAC-seq), and CUT&RUN for repressive chromatin marks (H3K27Me3) is visualized for each cell line in genome browser tracks. b Gli3 is in active chromatin and expressed in GHF-T1 cells. Gli3 is not expressed in TαT1 cells, and the chromatin is inaccessible with repressive marks. c Rxrg is expressed and in active chromatin in TαT1 cells, while not expressed and bearing repressive marks in GHF-T1 cells. N = 2 for histone marks/cell line