Table VIII.
Study | No. of women | No. of babies | Placental histology |
---|---|---|---|
Schoenmakers S et al | 1 | 1 negative | Placenta showed the presence of SARS-CoV-2 particles with generalized inflammation characterized by histiocytic intervillositis with diffuse perivillous fibrin depositions with damage to the syncytiotrophoblasts.The maternal side of the placenta had a viral load of 4.42 log copies /mL, while the fetal side had 7.15 log copies /mL. |
Hosier H et al | 1 | MTOP-negative | The placenta was remarkable for the presence of diffuse perivillous fibrin and an inflammatory infiltrate composed of macrophages as well as T lymphocytes, consistent with histiocytic intervillositis. SARS–CoV-2 localized predominantly to the syncytiotrophoblast cells of the placenta. |
Shanes ED | 16 | 15 babies negative 1 miscarriage- not tested |
Placentas show increased prevalence of decidual arteriopathy and other features of maternal vascular malperfusion, a pattern of placental injury reflecting abnormalities in oxygenation within the intervillous space associated with adverse perinatal outcomes. |
Kirtsman M et al | 1 | 1 positive | Placenta showed multiple areas of infiltration by inflammatory cells and extensive early infarction, largely confined to the intervillous space, consistent with chronic histiocytic intervillositis. There was extensive early necrosis of the syncytiotrophoblast layer. |
*MTOP- Medical termination of pregnancy