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. 2021 May;27(5):543–559. doi: 10.1261/rna.078428.120

FIGURE 2.

FIGURE 2.

Regions in the RNA recognition motif (RRM1) of the La protein play a role in La's RNA chaperone activity. (A) Schematic of the human and fission yeast La proteins. (NRE) Nuclear retention element. (SBM) Short basic motif. (NLS) Nuclear localization sequence. Schematics were generated with Ren et al. (2009). (B) Multiple sequence alignment (Madeira et al. 2019) of the conserved RNP1 and RNP2 sequences in the RRM1 of the human and fission yeast La proteins (Bayfield and Maraia 2009). (C) Ribbon representation of the high-resolution structure of the La motif and RRM1 of the human La protein in complex with a polyuridylate RNA oligomer (orange) (structure 2VOO from Kotik-Kogan et al. 2008), visualized in PyMOL (The PyMOL Molecular Graphics System, Version 1.8, Schrödinger, LLC). α-helices are pictured in cyan, β-sheets in pink. Regions important for RNA chaperone activity are highlighted: RNP1 and RNP2 (blue) and loop-3 (green).