Table 3.

The final model for time-varying analysis for the effect of CRBSI on mortality

Sensitivity Variables	Robust Std. Err	z-Value	Hazard ratio (95% Confidence Interval)	P-Value
Catheter-Related Bloodstream Infection	0.199	− 1.01	0.770 (0.464–1.279)	0.312
Urinary Tract Infection	0.395	0.47	1.170 (0.604–2.268)	0.642
Age 1st quartile (18–51) (reference)	1	1	1	1
Age 2nd quartile (52–66)	0.318	− 0.05	0.982(0.521–1.851)	0.956
Age 3rd quartile (67–77)	0.355	0.41	1.136(0.616–2.096)	0.683
Age 4th quartile (78–97)	0.568	2.24	1.933(1.087–3.437)	0.025
Medical (reference)	1	1	1	1
Surgical	0.114	− 3.21	0.398 (0.227–0.698)	0.001
Traumatology	0.189	− 1.68	0.579 (0.306–1.097)	0.094
APACHE 1st quartile (2–15) (reference)	1	1	1	1
APACHE 2nd quartile (16–19)	0.431	1.01	1.372(0.741–2.539)	0.314
APACHE 3rd quartile (20–25)	0.375	0.67	1.227(0.674–2.232)	0.504
APACHE 4th quartile (26–46)	0.666	2.45	2.142(1.165–3.938)	0.014
Diabetes mellitus	0.257	1.08	1.248(0.833–1.869)	0.282
Chronic renal failure	0.646	1.34	1.676 (0.788–3.566)	0.180
Corticosteroids	0.271	1.34	1.317 (0.880–1.972)	0.181
Anticoagulant	0.169	− 1.04	0.803(0.532–1.214)	0.299
Antibiotics	0.352	1.33	1.399(0.854–2.291)	0.182
Artificial respiration	0.509	0.21	1.100(0.444–2.722)	0.837
Positive end expiratory pressure	0.761	1.19	1.702(0.708–4.088)	0.234
Immediately new central venous catheter	0.662	2.97	2.329(1.334–4.066)	0.003
SOFA score 1st quartile (1–8) (reference)	1	1	1	1
SOFA score 2nd quartile (9–10)	0.361	0.51	1.169 (0.638–2.143)	0.613
SOFA score 3rd quartile (11–13)	0.441	1.3	1.474(0.820–2.651)	0.195
SOFA score 4th quartile (14–24)	0.664	2.65	2.216 (1.232–3.988)	0.008

APACHE Acute Physiology and Chronic Health Evaluation, CRBSI: Catheter Related Bloodstream Infection, SOFA Sequential Organ Failure Assessment