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. 2021 Apr 13;9:e11233. doi: 10.7717/peerj.11233

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© 2021 Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Volcano plot of ferroptosis-related DEGs between normal and LUAD tissues with |log2FC| > 1 and FDR < 0.01. Red dots represent 13 up-regulated genes and green dots represent eight down-regulated genes. (B) Univariate Cox regression analysis identified nine ferroptosis-related genes were related to overall survival (P < 0.05). (C) “Leave- one-out-cross-validation” for parameter selection in LASSO regression to filter out five candidate genes. (D) Survival analysis of CYBB, (E) CISD1, (F) VDAC2, (G) FADD, (H) SAT2. (I) The correlation network of five candidate genes. DEG, differentially expressed genes; FDR, false discovery rate.