Table 2:
Demographic and subcortical variables across control and NPC patient groupsa
| NPC | Controls | Variable | Significance (P) | Effect Size (η2)b | |
|---|---|---|---|---|---|
| Age (yr) | 31.50 (± 9.62) | 30.24 (± 9.78) | t = 0.348 | .730 | – |
| Sex (M/F) | 6:4 | 17:10 | χ2 = 0.024 | .869 | – |
| Intracranial volume (mm3) | 14.65 (± 2.30) × 105 | 15.07 (± 1.59) × 105 | t = 0.642 | .525 | – |
| Total gray matter (mm3) | 7.84 (± 0.69) × 105 | 8.44 (± 0.39) × 105 | F = 5.951 | .006 | 0.221 |
| Total white matter (mm3) | 6.36 (± 0.35) × 105 | 6.76 (± 0.35) × 105 | F = 5.327 | .01 | 0.198 |
| Left | |||||
| Hippocampus (mm3) | 3407 (± 654) | 4001 (± 457) | F = 12.201 | <.001c | 0.170 |
| Amygdala (mm3) | 1262 (± 299) | 1453 (± 211) | F = 3.234 | 0.052 | 0.104 |
| Thalamus (mm3) | 6297 (± 1111) | 8156 (± 781) | F = 18.168 | <.001c | 0.450 |
| Caudate (mm3) | 2966 (± 566) | 3421 (± 497) | F = 4.192 | .024 | 0.119 |
| Putamen (mm3) | 4229 (± 844) | 5163 (± 632) | F = 10.671 | <.001c | 0.236 |
| Pallidum (mm3) | 1526 (± 146) | 1726 (± 191) | F = 4.627 | .017 | 0.192 |
| Nucleus accumbens (mm3) | 473 (± 187) | 562 (± 117) | F = 3.150 | .056 | 0.039 |
| Right | |||||
| Hippocampus (mm3) | 3343 (± 739) | 4096 (± 451) | F = 17.641 | <.001c | 0.233 |
| Amygdala (mm3) | 1228 (± 220) | 1415 (± 245) | F = 14.472 | <.001c | 0.073 |
| Thalamus (mm3) | 6068 (± 1140) | 7847 (± 791) | F = 15.614 | <.001c | 0.423 |
| Caudate (mm3) | 3027 (± 68) | 3728 (± 558) | F = 6.458 | <.004c | 0.227 |
| Putamen (mm3) | 4101 (± 1188) | 5158 (± 495) | F = 15.238 | <.001c | 0.249 |
| Pallidum (mm3) | 1613 (± 272) | 1779 (± 144) | F = 4.168 | .024 | 0.121 |
| Nucleus accumbens (mm3) | 381 (± 131) | 465 (± 94) | F = 2.393 | .107 | 0.065 |
Note:— – indicates no statistical calculation.
a
Volumes are presented as means.
b
Effect sizes (Cohen d) presented for significant between-group comparisons.
c
P value surviving Holm-Bonferroni correction.