ER, FOXA1, and GATA3 have different predictive values for overall
survival based on race. A, Forest plot of HR of overall breast
cancer survival using median and population optimized cutoff
H-scores (ALL, EA, and AA) for ESR1, FOXA1, and GATA3
expression. B, Association between FOXA1 expression and survival in
low-risk, high-ER-expressing patient with breast cancer, comparing the total
population (left) with EA patients (center) and AA patients (right).
C, Association between GATA3 expression and survival in
low-risk, high-ER-expressing patients with breast cancer, comparing the total
population (left) with EA patients (center) and AA patients (right).
D, Univariate and multivariate logistic regression models of
overall breast cancer survival based on FOXA1, ESR1, and GATA3 expression
adjusted for age, race, and stage. 95% CIs are shown in parentheses.