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. 2021 Apr 14;41(15):3432–3445. doi: 10.1523/JNEUROSCI.1979-20.2021

Figure 4.

Figure 4.

Comparison of postural functions in control and knock-out mice. A, Relative number of trials in which control (N = 11, n = 94), V0Glut-KO (N = 5, n = 45), and V0-KO (N = 10, n = 75) mice performed successful righting in the first (1st), second (2nd), third (3rd), and fourth to ninth (4th–9th) attempt. B, Comparison of latencies of righting performed successfully from the first attempt in control (N = 6, n = 26), V0Glut-KO (N = 5, n = 29), and V0-KO (N = 10, n = 19) mice in trials in which the first attempt to perform righting was successful. C, Comparison of duration of 1st (St 1) and stage 2 (St 2) of the righting in control (N = 7, n = 47), V0Glut-KO (N = 5, n = 45), and V0-KO (N = 6, n = 64) mice. D, The mean (±SD) value of the tilt of the caudal part of the trunk in relation to vertical (angle β) in V0Glut-KO wild-type littermates [control (V0Glut-KO), N = 5, n = 26)], V0Glut-KO mice (N = 9, n = 24), V0-KO wild-type littermates [control (V0-KO), N = 3, n = 20)], and V0-KO mice (N = 6) standing on the horizontal platform. Note that V0-KO mice had different postures: two animals (n = 9) maintained vertical orientation of the caudal part of the trunk; in three animals (n = 13) it was tilted to the left; and in one animal (n = 3) it was tilted to the right. E, The mean (±SD) value of the coefficient of stabilization (K stabilization) exhibited by V0Glut-KO wild-type littermates (N = 5, n = 104), V0Glut-KO mice (N = 9, n = 157), V0-KO wild-type littermates (N = 3, n = 36), and V0-KO mice (N = 7, n = 161) during postural corrections caused by the lateral tilts of the supporting platform. F, Activity of the left Gast (Gast-L) and right Gast (Gast-R) recorded in V0-KO mice during postural corrections caused by the platform tilts. Statistically significant differences: in B, difference between values of the mean latency in control and V0Glut-KO mice (unpaired t test, t(7) = 3.74, p = 0.007), in control and in V0-KO mice (unpaired t test, t(10) = −4.69, p = 0.0008), in V0Glut-KO and V0-KO mice (unpaired t test, t(11) = −3.00, p = 0.01); in C, difference between values of the mean duration of St 1 and St 2 in V0Glut-KO mice (unpaired t test, t(8) = −8.05, p = 4.2 × 10−5) as well as in V0-KO mice (unpaired t test, t(10) = −4.57, p = 0.001), between the duration of St 1 in control and V0-KO mice (unpaired t test, t(6) = −6.95, p = 0.0004), between the duration of St 2 in control and V0Glut-KO mice (unpaired t test, t(6) = −10.27, p = 5.0 × 10−5), as well as in control and V0-KO mice (unpaired t test, t(5) = 8.29, p = 0.0004); in E, difference between values of K stabilization in V0-KO control and V0-KO mice (unpaired t test, t(8) = 4.36, p = 0.002), and between K stabilization in V0Glut-KO control and V0-KO mice (unpaired t test, t(3) = −3.66, p = 0.035).