TABLE 4.
Properties and names of the most commonly used BC CL
| Name | Properties | Type |
|---|---|---|
| MCF7 | ER+/PR+/HER2‐ | Luminal type A |
| MDAMB231 | ER‐/PR‐/HER2‐ | Triple negative |
| SkBr3 | ER+/PR+/HER2+ | HER2 positive |
| T‐47D | ER+/PR+/HER2‐ | Luminal type A |
| BT‐20 | ER‐/PR‐/HER2‐ | Triple negative |
| Molecular subtypes of cell lines | ||
|---|---|---|
| HER2 |
ER‐negative and HER2‐positive profile Over‐represented genomic profile on the chromosomal region 17q12 Present based on their profile, a bridge between luminal and basal cell lines Heterogeneous with luminal and basal features. |
|
| LUMINAL |
Expression of ER and or PR miRNA specific profile (eg hsa‐miR‐501‐5p, hsa‐miR‐202, hsa‐miR‐760 and hsa‐miR‐62) A subdivision into A (luminal A‐like; ER+, PR+, HER2‐, Ki‐67 low) and B (liminal B‐like; ER+, HER2‐; Ki‐67 high or PR low/‐; luminal B‐like, HER2 + m ER+, Ki‐67 any, PR any) Good differentiation, more intercellular tight junctions. |
|
| TNBC | TNBC basal A |
Common cytokeratins (KRT4/5/6A/6B/13/14/15/16/17) Integrins (ITGA6, ITGB4/6) Specific miRNA Better differentiation |
| TNBC basal B |
Higher expression of genes that promote aggressive behaviour (eg vimentin, moesin, plasminogen‐activating factor) CD44 + and CD24‐ Specific miRNA Worse differentiation |
|
Summarized based on the Cellosaurus database. 12