TABLE 7.
List of common cervical cancer cell lines
| Cell line | Patient | HPV status | Mutations | Primary tissue | Lit |
|---|---|---|---|---|---|
| C33A | 66Y | Negative |
MSI‐high DT – 1.36 d pseudodiploid p53 +; pRB + |
Cervical squamous cell carcinoma. Part of CCLE and COSMIC. |
Auersperg in 1964 86 |
| OMC‐4 (Osaka Medical College‐4) | 47Y | Negative |
Unknown MSI status DT – 63 h |
Cervical adenocarcinoma. | Yamada T et al in 1987 87 |
| CaSki | 40Y | Pos (HPV16) |
MSI stable no TP53 mutation beta subunit of human chorionic gonadotropin (hCG) |
Human papillomavirus‐related cervical squamous cell carcinoma. Metastatic site: Small intestine. Part of CCLE and COSMIC. |
Pattillo R.A in 1977 88 |
| SiHa | 55Y | Pos (HPV16) |
MSI stable DT – 2.6 d p53 +; pRB + hypertriploid CL |
Cervical squamous cell. Part of CCLE and COSMIC. |
Friedl F. et al in 1970 89 |
| HeLa | 30Y6M | Pos (HPV18) |
MSI stable DT – 1.3‐2 d Four marker chromosomes P53 low, pRB normal |
Endocervical adenocarcinoma. Part of CCLE and COSMIC. |
Gey GO et al in 1952 67 |
| TMCC‐1 | Age unspecified | Pos (HPV18) |
Unknown MSI status DT – 53 h |
Endocervical adenocarcinoma. Metastatic site: Pleural effusion. |
Sakamoto M. et al in 1987 90 |
| ME180 | 66Y | Pos (HPV68) |
MSI stable DT – 1.5 d P53 neg/pos, pRB + Heterozygous point mutation of PIK3CA p. Glu545Lys (c.1633G > A) |
Cervical squamous cell carcinoma Metastatic site: Omentum. Part of CCLE and COSMIC |
Sykes J. A. et al in 1970 91 |
| HT‐3 | 53‐58y a | Negative |
MSI stable hypotriploid to hypertriploid DT – 2.48 d p53 +; pRB + |
Metastatic site: Lymph node. Part of CCLE and COSMIC |
Fogh J. and Trempe G. (1975) 92 |
| C‐4‐I | 41Y | Pos (HPV18) |
MSI stable DT – 2 d |
cervical squamous cell carcinoma Part of CCLE and COSMIC |
Auersperg N in 1962 93 |
| C‐4‐II | 41Y | Pos (HPV18) |
MSI stable DT – 2.4 d |
cervical squamous cell carcinoma | Auersperg N in 1962. 93 |
| MS751 | 47Y |
Pos (HPV18) Pos (HPV45) |
MSI stable DT – 2.4 d hypodiploid human cell line |
epidermoid carcinoma Metastatic site: Lymph node Part of CCLE and COSMIC |
Sykes J. A. et al in 1974 |
| SW756 | 46y | Pos (HPV18) |
MSI stable DT – 1.6 d Expressed genes: HLA A1, A24, B8, B44, Cw2, Cx, DR6Y; Le3; Le4; Le5 |
squamous cell carcinoma | Leibovitz A. in 1974 |
Data summarized after the originators works as well as from the CELLOSAURUS databank.
Abbreviations: DT, doubling time; MSI, microsatellite.
Different indications – Indicated to be from a 58‐year‐old female patient on ATCC and from a 53‐year‐old on the Sloan Kettering tech transfer site.