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. 2021 Feb 23;25(8):3699–3713. doi: 10.1111/jcmm.15765

Figure 8.

Figure 8

Schematic representation of function of CAF‐derived exosomal miR‐24‐3p in CC. Exosomal miR‐24‐3p derived from CAFs was released after endocytosis by CC cells. miR‐24‐3p could target CDX2, and CDX2 could positively regulate HEPH. miR‐24‐3p contributed to promotion of CC cell resistance to MTX, while CDX2 and HEPH inhibited CC cell resistance to MTX