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. 2021 Feb 26;25(8):3714–3723. doi: 10.1111/jcmm.15976

FIGURE 1.

FIGURE 1

The expression of MEG3, miR‐214, EGFR mRNA and protein in the enrolled lung cancer patients grouped according to different SNP genotypes. A, The expression of MEG3 in lung cancer patients showed was not associated with the genotypes of rs884225 (TT, TC and CC), the genotypes of rs17337023 (TT, TA and AA) nor the haplotypes of MEG3 (GGGC, AAAT/GGGC and GAAT/GGGC). B, The expression of miR‐214 in lung cancer patients was not associated with the genotypes of rs884225 (TT, TC and CC), the genotypes of rs17337023 (TT, TA and AA) nor the haplotypes of MEG3 (GGGC, AAAT/GGGC and GAAT/GGGC). C, The expression of EGFR mRNA in lung cancer patients was not associated with the genotypes of rs17337023 (TT, TA and AA) nor the haplotypes of MEG3 (GGGC, AAAT/GGGC and GAAT/GGGC). However, level of EGFR mRNA was evidently increased in patients carrying CC genotype of rs884225 SNP compared with that in patients carrying TT and TC genotypes of rs884225 SNP. D, Western blot confirmed that the expression of EGFR protein was increased in lung cancer patients carrying CC genotype of rs884225 SNP compared with patients carrying TT and TC genotypes of rs884225 SNP. And EGFR protein expression was not associated with the genotypes of rs17337023 (TT, TA and AA) nor the haplotypes of MEG3 (GGGC, AAAT/GGGC and GAAT/GGGC)