TABLE 2.
Genotype and allele comparison between hypertension and control group
| Parameter | Control (N = 454) (%) | Hypertension (N = 436) (%) | OR (95% CI) | P value |
|---|---|---|---|---|
| MEG3 | ||||
| Haplotype | ||||
| GAAT | 18 (4) | 13 (3) | 1.12 (0.78‐1.23) | .365 |
| AAAT | 9 (2) | 17 (4) | ||
| GGGC | 249 (55) | 231 (53) | ||
| AAAT/GGGC | 72 (16) | 74 (17) | ||
| GAAT/GGGC | 90 (20) | 96 (22) | ||
| GAAT/AAAT | 16 (3) | 5 (1) | ||
| rs17337023 | ||||
| Genotype | ||||
| TT | 54 (12) | 65 (15) | 1.21 (0.82‐1.42) | .462 |
| AT | 272 (60) | 257 (59) | ||
| AA | 128 (28) | 114 (26) | ||
| TT + AT vs. AA | 326 (72) | 322 (74) | 1.18 (0.76‐1.32) | .583 |
| TT vs. AT + AA | 400 (88) | 371 (85) | 1.15 (0.72‐1.29) | .498 |
| Allele | ||||
| T | 380 (42) | 387 (44) | 1.38 (0.86‐1.34) | .521 |
| A | 528 (58) | 485 (56) | ||
| rs884225 | ||||
| Genotype | ||||
| TT | 131(29) | 87 (20) | 1.62 (1.19‐2.21) | |
| TC | 227 (50) | 178 (41) | .0021 | |
| CC | 96 (21) | 171(39) | ||
| TT vs. TC + CC | 323 (71) | 256 (61) | 0.83 (0.61‐1.51) | |
| TT + TC vs. CC | 358 (79) | 349 (80) | 1.82 (1.36‐2.44) | .271 |
| Allele | ||||
| T | 489 (53) | 352 (40) | 0.58 (0.48‐0.79) | <.0001 |
| C | 419 (47) | 520 (60) | <.0001 | |