FIGURE 1.

Ino80 was an essential gene required for early mouse embryonic development. (A) The mouse mutation strategy used in our study. (B) Representative images of uterus isolated from ± Ino80 mouse intercross breeding. Left image: numbers refer to individually implanted embryos. Embryos indicated by the red arrow were smaller and the genotyping revealed that they were Ino80−/−. Right images: isolated Ino80+/+ and Ino80−/− embryos at E8.5 and E10.5 showing defective morphology in Ino80−/− embryos. KO knockout, E embryonic day. (C) Representative images to show haematoxylin and eosin (HE) staining of Ino80+/+ and Ino80−/− embryos at E8.5. Scale bar = 2 mm