FIGURE 6.

Schematic representation of molecular mechanisms induced by sirt1 inhibition in ACC cells. Sirt1 inhibition reduces ERα expression (1). Reduction of ERα genomic action decreases CCND1 expression (2) influencing ACC cell proliferation. Reduction of ERα non‐genomic action decreases CREB phosphorylation and consequently IGF1R expression (3) influencing ACC cell proliferation. In addition, sirt1 inhibition causes ACC cell death by activating the intrinsic apoptotic pathway (4). Moreover sirt1 depletion reduces ACC cell motility regulating EMT process (5)