Table 4.

Population coverage analysis of optimized top scoring CTL epitopes for different target populations

Protein	Target population	Epitope	Percentage coverage	Total HLA hits
P0DTC2 Spike glycoprotein (S)	Europe	RVVVLSFEL	80.55%	31
		SLSSTASAL	77.12%	31
		YQPYRVVVL	75.44%	24
		AIVMVTIML	72.91%	18
		FVFLVLLPL	68.03%	20
		TSNQVAVLY	63.35%	26
		YLQPRTFLL	63.31%	26
		SIIAYTMSL	60.53%	33
	North America	RVVVLSFEL	80.83%	31
		SLSSTASAL	80.83%	31
		SIIAYTMSL	78.10%	33
		YQPYRVVVL	74.61%	24
		AIVMVTIML	69.55%	18
		TSNQVAVLY	67.13%	26
		VVNQNAQAL	64.63%	23
		YLQPRTFLL	64.56%	26
	South Asia	TSNQVAVLY	80.64%	26
		KTSVDCTMY	76.42%	23
		VLKGVKLHY	71.64%	17
		LSETKCTLK	66.63%	10
		MTSCCSCLK	66.63%	10
		TLLALHRSY	66.62%	13
		SIIAYTMSL	65.03%	33
		RVVVLSFEL	61.94%	31
	North East Asia	TSNQVAVLY	82.88%	26
		KTSVDCTMY	81.61%	23
		RVVVLSFEL	79.33%	31
		VLKGVKLHY	78.68%	17
		TLLALHRSY	76.97%	13
		SLSSTASAL	73.78%	31
		VVNQNAQAL	68.07%	23
		SIIAYTMSL	66.22%	33
P0DTC9 Nucleoprotein (N)	Europe	KAYNVTQAF	77.43%	27
		LSPRWYFYY	63.35%	26
		SPRWYFYYL	60.10%	14
		FPRGQGVPI	59.75%	12
	North America	KAYNVTQAF	76.89%	27
		LSPRWYFYY	67.13%	26
		DLSPRWYFY	54%	13
		SPRWYFYYL	51.20%	14
	South Asia	LSPRWYFYY	80.64%	26
		DLSPRWYFY	72.60%	13
		KAYNVTQAF	63.14%	27
		SPRWYFYYL	32.99%	14
	North East Asia	LSPRWYFYY	82.88%	26
		KAYNVTQAF	76.27%	27
		DLSPRWYFY	64%	13
		SPRWYFYYL	25.03%	14
P0DTD2 ORF9b protein	Europe	KISEMHPAL	88.15%	38
		KVYPIILRL	80.84%	20
		GPKVYPIIL	60.10%	15
		RLVDPQIQL	55.65%	14
	North America	KISEMHPAL	85.77%	38
		KVYPIILRL	77.80%	20
		RLVDPQIQL	55.50%	15
		GPKVYPIIL	51.20%	14
	South Asia	KVYPIILRL	76.77%	20
		KISEMHPAL	65.26%	38
		GPKVYPIIL	32.99%	14
		RLVDPQIQL	31.48%	15
	North East Asia	KVYPIILRL	81.77%	20
		KISEMHPAL	81.09%	38
		RLVDPQIQL	64.31%	15
		SLEDKAFQL	37.92%	13