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. 2021 Apr 16;7(16):eabg0880. doi: 10.1126/sciadv.abg0880

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2 — (A) Hydrodynamic sizes and photos of prodrug NPs. (B) Transmission electron microscopy (TEM) images of prodrug NPs. (C) Fluorescence spectral changes of prodrug NPs (1 μg ml⁻¹, CPT equivalent) after incubation with 10 mM dithiothreitol (DTT). (D) High-performance liquid chromatography (HPLC) determination of CSSP NPs incubated with 10 mM DTT. In vitro (E) CPT and (F) PR104A release of prodrug NPs incubated with different concentrations of DTT (n = 3). (G) ESI-MS of CSSP NPs when incubated with 1 mM DTT for approximately 2 hours and the drug release mechanism. ppm, parts per million. Photo credit: Dongyang Zhao, Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.