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. 2021 Apr 16;7(16):eabg0880. doi: 10.1126/sciadv.abg0880

Fig. 5. In vivo enhanced penetration of CSSP NPs in 4T1 tumor–bearing mice.

Fig. 5

(A) Plasma concentration–time profiles of total CPT in rats after intravenous injection of free CPT or prodrug NPs (2 mg kg−1, CPT equivalent) (n = 3). (B) In vivo near-infrared (NIR) fluorescence images of the heterotopic 4T1 tumor–bearing mice at 2, 4, 8, 12, and 24 hours after intravenous injection of free DiR or DiR-labeled prodrug NPs (1 mg kg−1, DiR equivalent). (C) Ex vivo NIR fluorescence images and (D) quantitative results of tumor and major organs collected at 24 hours. (n = 3). (E) Fluorescence images of 4T1 tumor sections and (F) quantitative results of CPT penetration after intravenous injection of various formulations. 4′,6-diamidino-2-phenylindole (DAPI), blue; CPT, green; CD31, red. Statistical significance: *P < 0.05.