Fig. 7. In vivo antimetastatic capacity of CSSP NPs against orthotopic 4T1 tumors.

(A) The tumor growth profiles, (B) tumor weights, and (C) tumor photos after various treatments (5.7 mg kg⁻¹, PR104A equivalent; 4 mg kg⁻¹, CPT equivalent) (n = 5). (D) Representative photographs of whole lungs of mice and H&E staining of the lung and liver. Red and yellow circles denote metastases. (E) The average number of surface lung metastases (n = 5). Statistical significance: **P < 0.01 and ***P < 0.001. Photo credit: Dongyang Zhao, Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.