Table 1.

Basic characteristics of included studies.

Auuthor		Year	Country	Age	Exosome type	Dysregulation	Sample (n)	Pathological type	Analysis method	Detection method	Oncologic outcomes	NOS
Zhang		2020	China	57.4	miR-378	Upregulation	103	NSCLC	MVA	qRT-PCR	OS	8
Xue		2020	China	NA	miR-151a-5p	Upregulation	6	ADC	UVA	qRT-PCR	OS	7
					miR-10b-5p	Upregulation	6	ADC	UVA	qRT-PCR	OS
					miR-192-5p	Upregulation	6	ADC	UVA	qRT-PCR	OS
					miR-106b-3p	Upregulation	6	ADC	UVA	qRT-PCR	OS
					miR-484	Upregulation	6	ADC	UVA	qRT-PCR	OS
Xiong		2020	China	NA	miR-214	Upregulation	100	NSCLC	UVA	qRT-PCR	OS	6
Shimada		2020	Japan	NA	UCHL1	Upregulation	72	SCLC	MVA	qRT-PCR	DFS	7
Nanou		2020	Netherland	65	tDEVs	Upregulation	137	NSCLC	UVA	Cell search	OS	8
Xu		2019	China	64	miR-32	Downregulation	43	NSCLC	UVA	qRT-PCR	OS/PFS	6
Sun		2019	China	NA	miR-423-3p	Upregulation	155	ADC	MVA	qRT-PCR	OS	7
					miR-4270	Downregulation	155	ADC	MVA	qRT-PCR	OS
Yunwen		2018	China	NA	miR-425-3p	Upregulation	170	NSCLC	UVA	qRT-PCR	PFS	8
Li		2018	China	NA	FECRS	Downregulation	56	SCLC	UVA	qRT-PCR	PFS	7
Koh		2018	Korea	66	Rab27B	Upregulation	96	SQCC/ADC	MVA	IHC	DFS/DSS	6
					Rab27B	Upregulation	37	SQCC/ADC	MVA	IHC	DFS/DSS
Xu		2018	China	60	miR-21	Upregulation	437	ADC	UVA	qRT-PCR	OS	7
Kanaoka		2018	Japan	NA	miR-451a	Upregulation	285	NSCLC	MVA	qRT-PCR	OS/DFS	9
Zeng		2017	China	55	LncRNA	Upregulation	86	SCLC	MVA	qRT-PCR	OS	7
Dejima		2017	Japan	NA	miR-21	Upregulation	201	NSCLC	MVA	qRT-PCR	DFS	7
					miR-4257	Upregulation	201	NSCLC	MVA	qRT-PCR	DFS
Liu		2016	China	58.5	miR-23b-3p	Upregulation	196	NSCLC	MVA	qRT-PCR	OS	8
					miR-10b-5p	Upregulation	196	NSCLC	MVA	qRT-PCR	OS
					miR-21-5p	Upregulation	196	NSCLC	MVA	qRT-PCR	OS
Paulsen-S		2016	Danmark	68.6	Alix	Upregulation	276	NSCLC	MVA	Spotbot	OS	8