Table 2.
Summary of overall and subgroup analyses for exosomes on OS.
| Studies (n) | Combined HR (95%CI) | Weight (%) | I2 | P-value (Q) | |
| overall | 18 | 2.01 (1.70-2.39) | 100.0 | 67.8% | .000 |
| Country | |||||
| China | 15 | 1.98 (1.62–2.42) | 83.53 | 68.7% | .000 |
| Other countries | 3 | 2.43 (1.45–4.08) | 16.47 | 72.5% | .026 |
| Sample size | |||||
| >100 | 11 | 2.48 (1.95–3.15) | 56.41 | 68.1% | .001 |
| <100 | 7 | 1.50 (1.27–1.77) | 43.59 | 30.2% | .198 |
| Detection method | |||||
| qRT-PCR | 15 | 2.08 (1.69–2.55) | 86.09 | 71.2% | .000 |
| Non qRT-PCR | 3 | 1.82 (1.56–2.11) | 13.91 | 0.0% | .424 |
| Analysis method | |||||
| MVA | 10 | 2.90 (2.17–3.86) | 46.88 | 69.1% | .001 |
| UVA | 8 | 1.46 (1.30–1.65) | 53.12 | 0.0% | .877 |
| Pathological type | |||||
| NSCLC | 9 | 2.19 (1.80–2.67) | 45.72 | 38.9% | .109 |
| ADC | 8 | 2.01 (1.70–2.39) | 50.78 | 75.4% | .000 |
| SCLC | 1 | 3.76 (1.83–7.71) | 3.50 | – | – |