Table 3.
Top 15 Allergens Eliciting the Highest Reaction Rates in the Following Four Populations: Mayo Clinic 2013–2017 with Eyelid Involvement, Mayo Clinic 2013–2017 without Eyelid Involvement, NACDG 2013–2014, and MCCDG 2011–2015 General Patch Test Populations (Sorted by Descending Positivity)
| Rank | Mayo Clinic 2013–2017 with Eyelid Involvement | Mayo Clinic 2013–2017 without Eyelid Involvement | NACDG 2013–2014 | MCCDG 2011–2015 |
|---|---|---|---|---|
| 1 | Nickel (ll) sulfate hexahydrate 2.5% | Nickel (ll) sulfate hexahydrate 2.5% | Nickel sulfate, 2.5% pet | Gold sodium thiosulfate, 2% |
| 2 | Shellac 20% in alc. | Methylisothiazolinone 0.2% aqa | Fragrance mix I, 8% pet | Nickel sulfate hexahydrate, 2.5% |
| 3 | Thimerosal 0.1% | Myroxylon pereirae resin 25% | MI, 0.2% aq | Myroxylon pereirae resin, 25% |
| 4 | Cobalt (II) chloride hexahydrate 1% | Thimerosal 0.1% | Neomycin, 20% pet | Gold (I) sodium thiosulfate dehydrate, 0.5% |
| 5 | Neomycin sulfate 20% | Shellac 20% in alca | Bacitracin, 20% pet | Methylisothiazolinone, 0.2% aqueous |
| 6 | Gold (I) sodium thiosulfate dihydrate 0.5% in pet | Cobalt (II) chloride hexahydrate 1% | Cobalt chloride, 1% pet | Benzalkonium chloride, 0.1% aqueous |
| 7 | Methylisothiazolinone 0.2% aq | Neomycin sulfate 20% | Myroxylon pereirae, 25% pet | Cobalt (II) chloride hexahydrate, 1% |
| 8 | Myroxylon pereirae resin 25% | Gold (I) sodium thiosulfate dihydrate 0.5% in pet | p-Phenylenediamine, 1% pet | Fragrance mix, 8% |
| 9 | Bacitracin 20% | Fragrance mix 8%a, b | Formaldehyde, 2% aq | Neomycin sulfate, 20% |
| 10 | Potassium dichromate 0.25% | Potassium dichromate 0.25% | MCI/MI, 0.01% aq | Potassium dichromate, 0.25% |
| 11 | 2-Hydroxyethyl methacrylate 2% (HEMA) | Hydroperoxides of linalool 1.0%b | Fragrance mix II, 14% pet | Carba mix, 3% |
| 12 | Benzalkonium chloride 0.1% aq | MCI/MI 100 ppm aq | Formaldehyde, 1% aq | Benzoic acid, 5% |
| 13 | MCI/MI 100 ppm aq | Bacitracin 20% | Lanolin alcohol (Amerchol L 101), 50% pet | Propolis, 10% |
| 14 | Propolis 10% | Methyldibromo glutaronitrile 0.5%a, b | Carba mix, 3% pet | Methyldibromo glutaronitrile/phenoxyethanol, 1.5% |
| 15 | Hydroperoxides of linalool 1.0% | Carba mix 3%a, b | Quaternium-15, 2% pet | Bacitracin, 20% |
Notes: aAllergens with the greatest difference between those with eyelid involvement and without (3.9% difference or greater). bAllergens in the top 15 without eyelid involvement not found in the top 15 with eyelid involvement.