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. 2021 Apr 12;15:1477–1490. doi: 10.2147/OPTH.S297754

Table 4.

The 25 Allergens That Did Not Elicit Positive Reactions in Mayo Clinic 2013–2017 Patients with Eyelid Involvement, But Did Elicit Positive Reactions in NACDG 2013–2014 and MCCDG 2011–2015 General Patch Test Populations (Sorted in Alphabetical Order)

Allergen Eyelid Involvement No Eyelid Involvement Mayo Standard Series 2011–2015 (Positive Rxn Rate/N of Patients) NACDG Standard Series 2013–2014 (Table 6) (Positive Rxn Rate/N of Patients)
Number of Patients Tested Positive, n (%) Negative, n (%) Irritant, n (%) Relevancy Among Those Testing Positive, n (%) Number of Patients Tested Positive, n (%) Negative, n (%) Irritant, n (%) Relevancy Among Those Testing Positive, n (%)
2-Phenoxyethanol 1% 192 0 192 (100.0%) 0 1693 3 (0.2%) 1686 (99.6%) 4 (0.2%) 3/3 (100.0%) 0.5%/988
Benzocaine 5% 215 0 215 (100.0%) 0 1973 30 (1.5%) 1937 (98.2%) 6 (0.3%) 27/30 (90.0%) 1.9%/2569 1.6%/4851
Cananga odorata oil 2% 88 0 87 (98.9%) 1 (1.1%) 414 6 (1.4%) 407 (98.3%) 1 (0.2%) 6/6 (100.0%) 1.2%/4859
Cetyl alcohol 5% 215 0 215 (100.0%) 0 1975 4 (0.2%) 1968 (99.6%) 3 (0.2%) 4/4 (100.0%) 0.3%/2574
Chloroxylenol (PCMX) 1% 215 0 215 (100.0%) 0 1974 12 (0.6%) 1956 (99.1%) 6 (0.3%) 12/12 (100.0%) 0.8%/2573 0.5%/4859
Cinnamal (cinnamic aldehyde) 1% 215 0 214 (99.5%) 1 (0.5%) 1974 27 (1.4%) 1945 (98.5%) 2 (0.1%) 27/27 (100.0%) 1.9%/2571 4.2%/4858
Clobetasol-17-propionate 1% 215 0 215 (100.0%) 0 1973 7 (0.4%) 1964 (99.5%) 2 (0.1%) 7/7 (100.0%) 1.1%/2572 0.1%/4859
Cocamidopropyl betaine 1% aq 215 0 210 (97.7%) 5 (2.3%) 1973 50 (2.5%) 1904 (96.5%) 19 (1.0%) 49/50 (98.0%) 5.5%/2573 1.6%/4859
Desoximetasone 1% 68 0 68 (100.0%) 0 556 0 555 (99.8%) 1 (0.2%) 0.1%/4859
Dimethylol dihydroxyethylene urea 4.5% aq 215 0 214 (99.5%) 1 (0.5%) 1974 8 (0.4%) 1955 (99.0%) 11 (0.6%) 8/8 (100.0%) 0.5%/2573
Epoxy resin, bisphenol A 215 0 215 (100.0%) 0 1972 19 (1.0%) 1941 (98.4%) 12 (0.6%) 19/19 (100.0%) 1.6%/2574 1.8%/4857
Ethyleneurea–melamine formaldehyde mix 5% 215 0 215 (100.0%) 0 1974 21 (1.1%) 1940 (98.3%) 13 (0.7%) 20/21 (95.2%) 1.3%/2573
Ethylhexylglycerin 5% 11 0 11 (100.0%) 0 89 0 89 (100.0%) 0 0.2%/4859
Glutaral (glutaraldehyde) 0.2% 215 0 215 (100.0%) 0 1975 8 (0.4%) 1952 (98.8%) 15 (0.8%) 8/8 (100.0%) 0.8%/2574
Hexylresorcinol 0.25% 193 0 192 (99.5%) 1 (0.5%) 1603 31 (1.9%) 1561 (97.4%) 11 (0.7%) 30/31 (96.8%) 3.3%/2573
Lavandula angustifolia oil 2% 142 0 142 (100.0%) 0 747 13 (1.7%) 731 (97.9%) 3 (0.4%) 13/13 (100.0%) 0.3%/4859
Mentha piperita oil (peppermint oil) 2% 140 0 139 (99.3%) 1 (0.7%) 748 9 (1.2%) 738 (98.7%) 1 (0.1%) 9/9 (100.0%) 0.6%/4859
Mercapto mix 1% 215 0 214 (99.5%) 1 (0.5%) 1971 7 (0.4%) 1957 (99.3%) 7 (0.4%) 7/7 (100.0%) 0.5%/2571
Mercaptobenzothiazole 1% 215 0 214 (99.5%) 1 (0.5%) 1971 7 (0.4%) 1954 (99.1%) 10 (0.5%) 7/7 (100.0%) 0.7%/2573 0.5%/4859
Methyldibromo glutaronitrile/phenoxyethanol 1% 54 0 53 (98.1%) 1 (1.9%) 391 10 (2.6%) 369 (94.4%) 12 (3.1%) 10/10 (100.0%) 6.2%/1121
Mixed dialkyl thioureas 1% 215 0 214 (99.5%) 1 (0.5%) 1974 14 (0.7%) 1954 (99.0%) 6 (0.3%) 13/14 (92.9%) 1.0%/4859
Sodium-2-pyridinethiol-1-oxide 0.1% aq 90 0 90 (100.0%) 0 452 1 (0.2%) 451 (99.8%) 0 1/1 (100.0%) 0.9%/4859 0.9%/2539
Sorbic acid 2% 215 0 215 (100.0%) 0 1975 9 (0.5%) 1959 (99.2%) 7 (0.4%) 9/9 (100.0%) 0.6%/2573
Sorbitan sesquioleate 20% 215 0 215 (100.0%) 0 1975 9 (0.5%) 1953 (98.9%) 13 (0.7%) 9/9 (100.0%) 0.7%/1689
Tea tree oil, oxidized 5% 215 0 215 (100.0%) 0 1973 48 (2.4%) 1916 (97.1%) 9 (0.5%) 47/48 (97.9%) 2.4%/1687 0.9%/4859
Triamcinolone acetonide 1% 214 0 214 (100.0%) 0 1966 1 (0.1%) 1961 (99.7%) 4 (0.2%) 1/1 (100.0%) 0.4%/2561