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. 2021 Apr 12;16:2789–2801. doi: 10.2147/IJN.S299515

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© 2021 Zhang et al.

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Effects of Wnt/β-catenin inhibitor KYA1797K on Cit-NRIII-induced osteogenic differentiation. (A) ALP staining and (B) ALP activity level of MC3T3-E1 cells after treated with Cit-NRIII alone or combine with KYA1797K for 14 days, respectively. (C) Mineralized nodules stained with alizarin red S and (D) Calcium deposition assay of MC3T3-E1 cells after treated with Cit-NRIII alone or combine with KYA1797K for 21 days, respectively. (E–H) Real-time PCR analysis of ALP, Runx2, COL1 and OPN, mRNA expression of MC3T3-E1 cells after treated with Cit-NRIII alone or combine with KYA1797K for 3, 5 and 7 days, respectively. Asterisk indicates statistically significant differences between control and experience group (*p < 0.05; **p < 0.01; ***p < 0.005).