Table 1.

Effect of RA Medication on Diabetes and Insulin Resistance

Name of Drug	Insulin Resistance	HbA1c	Diabetes Risk	Insulin Sensitivity	References
Glucocorticoid	↑	↑	↑	↓	60,61,64,100,101
Hydroxychloroquine	–	↓↓	↓	↑	95,96,98,102
Methotrexate	↓	↓	–	↑	96,98,103
TNF antagonists	↓	↓	↓	↑	15,78,104
Interleukin-1β antagonist	↑	↓	↓	-	83,105
Interleukin-6 antagonist	↓	↓	↓	-	106

Note: Arrows significant the association of drug with insulin resistance, HbA1c, diabetes risk, insulin sensitivity.

Abbreviations: ↑, increase; ↓, decrease; ↓↓, larger decrease; HbA1c, glycosylated hemoglobin.