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Comparison of BBB permeability properties.
| Properties | Ref1 | Ref2 | JTP-4819 | Metergoline | Pipercallosine | Hookerianamide J | Lobeline |
|---|---|---|---|---|---|---|---|
| Molecular weight (Da) | 344.5 | 384.5 | 359.185 | 403.517 | 329.433 | 442.677 | 337.455 |
| logP | 2.378 | 3.203 | 0.527 | 4.249 | 4.758 | 4.935 | 3.933 |
| Polar surface area (Å2) | 65.92 | 65.92 | 89.94 | 46.5 | 47.56 | 52.57 | 40.54 |
| Hydrogen bond donor | 0 | 0 | 2 | 1 | 1 | 2 | 1 |
| Hydrogen bond acceptor | 3 | 3 | 4 | 3 | 3 | 3 | 3 |
| N + O atoms | 4 | 4 | 7 | 5 | 4 | 4 | 3 |
