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Advantages and disadvantages of human in vitro microglia models.
| Model | Strengths | Limitations |
|---|---|---|
| hiPSC | High purity | Expensive |
| Ability to self-renew | Time consuming | |
| Developmental model | ||
| Primary macrophages | Can obtain from adult donors | Limited supply |
| Different ontogeny | ||
| Immortalised cell line | Fast | Karyotype abnormalities |
| Ability to self-renew | Abnormal proliferative state | |
| Currently reliant on serum affecting reactivity |
