Table 3.
Enrichment analysis of genes differentially spliced in PE
| Gene Set | Description | Expect | Ratio | p value | FDR |
|---|---|---|---|---|---|
| Gene ontology biological processes | |||||
| GO: 0,016,192 | Vesicle-mediated transport | 70.148 | 1.6394 | 4.34E–08 | 0.000199 |
| GO: 0,030,198 | Extracellular matrix organization | 12.534 | 2.7924 | 4.37E–08 | 0.000199 |
| GO: 0,043,062 | Extracellular structure organization | 14.449 | 2.4916 | 4.80E–07 | 0.001455 |
| GO: 0,006,887 | Exocytosis | 32.293 | 1.889 | 1.25E–06 | 0.002845 |
| GO: 0,072,359 | Circulatory system development | 37.061 | 1.8078 | 1.7E–06 | 0.003095 |
| GO: 0,031,102 | Neuron projection regeneration | 1.8783 | 5.3239 | 1.41E–05 | 0.021369 |
| GO: 0,031,103 | Axon regeneration | 1.5532 | 5.7944 | 1.85E–05 | 0.024045 |
| GO: 0,048,678 | Response to axon injury | 2.4201 | 4.5452 | 2.55E–05 | 0.028951 |
| GO:0,035,295 | Tube development | 35.832 | 1.7024 | 3.19E–05 | 0.030548 |
| GO: 0,045,055 | Regulated exocytosis | 28.283 | 1.8032 | 3.38E–05 | 0.030548 |
| KEGG pathways | |||||
| hsa04510 | Focal adhesion | 7.8332 | 2.6809 | 3.33E–05 | 0.010845 |
| hsa04512 | ECM-receptor interaction | 3.2277 | 3.408 | 0.000337 | 0.05495 |
| hsa04960 | Aldosterone-regulated sodium reabsorption | 1.4564 | 4.8063 | 0.000507 | 0.055129 |
| Reactome pathways | |||||
| R-HSA-1474244 | Extracellular matrix organization | 11.893 | 2.8589 | 2.91E–08 | 5.03E–05 |
| R-HSA-216083 | Integrin cell surface interactions | 3.3584 | 4.7641 | 1.70E–07 | 0.000147 |
| R-HSA-114608 | Platelet degranulation | 5.0969 | 2.9429 | 0.000168 | 0.078328 |
| Disease_GLAD4U | |||||
| PA443275 | Adhesion | 22.33 | 2.4183 | 2.04E–09 | 5.55E–06 |
| PA443553 | Brain diseases | 16.179 | 2.2251 | 7.22E–06 | 0.008322 |
| PA166048714 | Pregnancy | 11.194 | 2.5013 | 9.18E–06 | 0.008322 |
| PA443657 | Central nervous system diseases | 16.674 | 2.159 | 1.39E–05 | 0.009476 |
| PA444447 | Carcinoma, hepatocellular | 11.077 | 2.4374 | 2.1E–05 | 0.011403 |
| PA443853 | Dementia | 8.1915 | 2.6857 | 2.83E–05 | 0.012844 |
| PA445403 | Pregnancy complications | 8.4538 | 2.6024 | 4.57E–05 | 0.016622 |
| PA166123006 | interstitial fibrosis | 2.128 | 4.6992 | 4.89E–05 | 0.016622 |
| PA443812 | Cri-du-chat syndrome | 0.46642 | 10.72 | 6.92E–05 | 0.020562 |
| PA445080 | Neovascularization, pathologic | 6.3841 | 2.8195 | 8E–05 | 0.020562 |
| Disease_OMIM | |||||
| 146,110 | Hypogonadotropic hypogonadism 7 with or without anosmia | 0.11153 | 35.866 | 3.14E–06 | 0.000207 |
| 611,162 | Malaria, susceptibility to malaria, resistance to, included | 0.13542 | 29.537 | 7.35E–06 | 0.000242 |
| 152,700 | Systemic lupus erythematosus | 0.063729 | 31.383 | 0.001671 | 0.036762 |
| 104,300 | Alzheimer disease | 0.087628 | 22.824 | 0.003234 | 0.053355 |