REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse anti-PAF (KIAA0101)	Santa Cruz Biotechnology	Cat# sc-390515
Mouse anti-PAF (KIAA0101)	Abcam	Cat# ab56773; RRID: AB_943922
Mouse anti-PAF (KIAA0101)	Abcam	Cat# ab226255
Rabbit anti-PCNA	Cell Signaling Technology	Cat# 13110; RRID: AB_2636979
Rabbit anti-Ki67	Abcam	Cat# ab16667; RRID: AB_302459
Rabbit anti-Cleaved Caspase-3	Cell Signaling Technology	Cat# 9664; RRID: AB_2070042
Mouse anti-RBBP4 (13D10)	GeneTex	Cat# GTX70234; RRID: AB_372871
Rabbit anti-RBBP4	Bethyl	Cat# A301-206A; RRID: AB_890631
Mouse anti-LIN9	Santa Cruz Biotechnology	Cat# sc-398234
Mouse anti-p130 (RBL2)	Cell Signaling Technology	Cat# 13610S; RRID: AB_2798274
Rabbit anti-E2F4	Bethyl	Cat# A302-134A; RRID: AB_1720353
Mouse anti-E2F4	Santa Cruz Biotechnology	Cat# sc-398543
Rabbit anti-LIN54	Bethyl	Cat# A303-799A; RRID: AB_11218173
Rabbit anti-B MYB (phosphor T487)	Abcam	Cat# ab76009; RRID: AB_1309969
Mouse anti-FOXM1 (G-5)	Santa Cruz Biotechnology	Cat# sc-376471; RRID: AB_11150135
Rabbit anti-alpha-Tubulin	Cell Signaling Technology	Cat# 2144; RRID: AB_2210548
Rabbit anti-RAS (mutated G12D)	Abcam	Cat# ab221163
Mouse Anti-FLAG (M2)	Sigma-Aldrich	Cat# F3165; RRID: AB_259529
Mouse anti-HA (3F10)	Roche	Cat# 11867423001; RRID: AB_390918
Rabbit Anti-Mouse IgG (Light Chain Specific) (D3V2A) HRP Conjugate	Cell Signaling Technology	Cat# 58802; RRID: AB_2799549
Chemicals, peptides, and recombinant proteins
Harmine	Abcam	Cat# ab120225
Pitavastatin	Selleckchem	Cat# S1759
Cyclosporin A	Selleckchem	Cat# S2286
Experimental models: cell lines
H322	ATCC	Cat# CRL-5806
H358	ATCC	Cat# CRL-5807
A549	ATCC	Cat# CCL-185
H23	ATCC	Cat# CRL-5800
H1299	ATCC	Cat# CRL-5803
H1355	ATCC	Cat# CRL5865
H1792	ATCC	Cat# CRL-5895
H1975	ATCC	Cat# CRL-5908
H460	ATCC	Cat# HTB-177
NIH/3T3	ATCC	Cat#CRL-1658
Biological samples
Human normal lung samples	Laboratory of Dr. Bingliang Fang (MDACC)	N/A
TC241(PDX)	Laboratory of Dr. Bingliang Fang (MDACC)	N/A
TC303 (PDX)	Laboratory of Dr. Bingliang Fang (MDACC)	N/A
TC314 (PDX)	Laboratory of Dr. Bingliang Fang (MDACC)	N/A
Experimental models: organisms/strains
Mouse: B6.129S4-Krastm4Tyj/J	The Jackson Laboratory	JAX:008179; RRID: IMSR_JAX:008179
Mouse: B6.129P2-Trp53tm1Brn/J	The Jackson Laboratory	JAX:008462; RRID: IMSR_JAX:008462
Mouse: NOD.CB17-Prkdcscid/J	The Jackson Laboratory	JAX: 001303; RRID: IMSR_JAX:001303
Mouse: J:NU	The Jackson Laboratory	JAX: 007850; RRID: IMSR_JAX:007850
Recombinant DNA
Human shPAF #1	Sigma	TRCN0000278496
Human shPAF #2	Sigma	TRCN0000278497
shGFP	Sigma	SHC005
Mouse shPAF #1	Dharmacon	V2LMM_11233
Mouse shPAF #2	Dharmacon	V2LMM_16348
Human shDYRK1A	Dharmacon	V2LHS_113582
GIPZ shRNA Empty	Dharmacon	RHS4349
pLenti-FLAG-PAF	This paper	N/A
pLenti-FLAG-PAF mutRBM	This paper	N/A
pLenti-FLAG-PAF mutPIP	This paper	N/A
pLenti-FLAG-PAF mutPIP, mutRBM	This paper	N/A
pLenti-FLAG-PAF K15R	This paper	N/A
pLenti-FLAG-PAF K24R	This paper	N/A
pLenti-FLAG-PAF K15R/K24R	This paper	N/A
pCDNA-FLAG-PAF	This paper	N/A
pCDNA-FLAG-RBBP4	This paper	N/A
pCDNA-FLAG-RBBP4 Δ347-362	This paper	N/A
pCDNA-FLAG-RBBP4 Δ348-352	This paper	N/A
CSII-EF-DHB-mVenus	(Spencer et al., 2013)	N/A
pLentiCRISPRv2-hygro	Addgene	Cat# 98291
Software and algorithms
GSEA software	Broad Institute of MIT and Harvard University	https://www.gsea-msigdb.org/gsea/index.jsp
CONNECTIVITY MAP (CMap)	Broad Institute of MIT	https://clue.io/cmap
GraphPad Prism 7	GraphPad	https://www.graphpad.com/scientific-software/prism/
ImageJ	ImageJ	https://imagej.net/Fiji
FlowJo	FlowJo LLC	https://www.flowjo.com/solutions/flowjo/
Critical commercial assays
TnT Quick Coupled Transcription/Translation System	Promega	Cat# L1170
Deposited data
RNA-Seq dataset	This paper	GEO: GSE136571 and GSE147305
Oligonucleotides
Primers for qPCR, ChIP assay, and genotyping	This paper (Table S7)	N/A