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. Author manuscript; available in PMC: 2022 Apr 15.
Published in final edited form as: Mol Cell. 2021 Feb 26;81(8):1816–1829.e5. doi: 10.1016/j.molcel.2021.02.004

Figure 6. The unified ALT pathway produces survivors with “Hybrid” structure.

Figure 6.

(A) The ONT analysis of tlc1Δ survivor ZK-17 with >32 Y’ elements demonstrate “hybrid” chromosome end structure.

(B) Unstable (Type I) survivor ZK-2 from tlc1Δ; see the graphical legend in (A).

(C) Changes of Y’ copy number during passaging of the unstable survivor shown in (B) by ddPCR for each of 10 passages of 250 cells/ml in 4ml (similar to Figure 1B).

(D) The chromosomal end structure of the stable ALT survivor obtained after 10 passages described in (C).

(See also Figure S5 and Table S3)