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. 2021 Apr 16;11:8398. doi: 10.1038/s41598-021-87094-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in the rates of genetic alteration detection in cfDNA among truncal, shared and individual alterations. (A) The pie charts show the differences in the number of genetic alterations detected in all 6 patients combined according to the mutation type (truncal, shared or individual). The values represent the numbers of genetic alterations. The red colors of the charts represent the number of genetic alterations both in cfDNA and tDNA. White represents only those in tDNA. The detection rate in cfDNA was highest for individual mutations and lowest for truncal mutations. (B) The figures show the total number of genetic alterations in each tumor sample of each patient. The height of each column represents the proportion of genetic alterations detected, and the total column height represents the total number of genetic alterations in each patient. The brown bars represent the genetic alterations detected in all tumor lesions (truncal), green bars represent the genetic alterations detected in more than one but not all lesions (shared), and the blue bars represent the genetic alterations detected in only one lesion (individual). The red bars represent the corresponding alterations detected in cfDNA. (C) The heatmaps were constructed using functional alterations. One line corresponds to one genetic alteration. Abbreviations: cfDNA, cell-free DNA.