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. 2021 Apr 16;4:481. doi: 10.1038/s42003-021-01999-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b The density maps of immature Gag CA-SP1 from Gag_ΔMAT8I assemblies (a) and GagT8I VLPs (b), overlaid with the refined respective atomic models shown in blue (CA_NTD) and orange (CA_CTD-SP1). Domain regions are labelled. c Enlarged views of CypA-binding loop (CypA-BL) and N-terminal MA-CA linker in Gag_ΔMAT8I assemblies (top) and GagT8I VLPs (bottom). d Detailed views of the central densities within the six-helix bundle of Gag_ΔMAT8I assemblies (left), GagT8I VLPs (middle) and Gag_ΔMAT8I assemblies with 10 µM IP6 (right). Black arrows point to the lysine residues from CA_CTD, K158 and K227, forming two-rings to coordinate a central density (red arrows). Dashed lines mark the same height in both density maps.