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. 2021 Apr 16;12:2294. doi: 10.1038/s41467-021-22276-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Hetero- (yellow/green) and homo- (red) oligomeric helical bundles are fused to de novo helical repeat proteins (shades of blue) (left) to create a wide range of building blocks using HelixDock and HelixFuse (center). Symmetric units shown in gray. b Twenty representative HelixFuse outputs overlaid in groups of five display the wide range of diversity that can be generated by using a single helical bundle core (symmetric units hidden for clarity). c Building blocks are further assembled into higher-ordered structures through helical fusion (WORMS). The examples are cyclic crowns (top), dihedral rings (middle), and icosahedral nanocages (bottom); additional details available in their respective sections.