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. 2021 Apr 16;5:32. doi: 10.1038/s41698-021-00170-7

Fig. 5. Identification of LY2409881 as a potent EGFR-L747P mutant inhibitor.

Fig. 5

a Growth inhibition curve details. EGFR mutant expressing Ba/F3 cells treated with serially diluted LY2409881. After 72 h of drug treatment, cell viability was measured using the CellTiter-Glo assay (n = 3). b Chemical structure of LY2409881. c Inhibition of EGFR phosphorylation in the Ba/F3 cells expressing EGFR-L747P or EGFR-L858R mutation treated with 600 nM of LY2409881 for 3 h was evaluated by western blot with the indicated antibodies.