Fig. 10. Some Genes Enriched in IL-11⁺ Fibroblasts is correlated with reduced recurrence disease-free durations in human CRC.

a Expression levels of genes enriched in IL-11⁺ fibroblasts are elevated in human colon cancer tissues. From the data set (GSE33113), we retrieved the expression levels of the genes enriched in IL-11⁺ fibroblasts described in Fig. 4. The signaling intensities of each gene in normal mucosa (n = 6) and colon cancer tissues (n = 90) are shown by box-and-whisker plots. Boxes and whiskers show the 25th–75th percentile with the median and the minimum–maximum, respectively. b–d Upregulation of a set of genes enriched in IL-11⁺ fibroblasts (IL11FS) is correlated with reduced recurrence-free survival durations in colon cancer patients. GSE17536 and GSE17537 were obtained from the Gene Expression Omnibus. Based on the expression patterns of IL11, signature genes of IAFs (IL11/IL24/IL13A2/TNFRSF11B), or IL11FS, we classified patients into two respective clusters using the hierarchical clustering method. The recurrence-free durations of each group was calculated using the Kaplan–Meier method. Statistical significance was determined using two-sided Mann–Whitney U test (a) or two-sided Mantel-Cox Log-rank test (b–d). Source data are provided as a Source Data file.