Fig. 2. Detailed contacts in the p53/BCL-xL complex.

a Key interactions at the p53 dimer interface. Involved residues are shown as sticks. Polar contacts are shown as black dotted lines. Red spheres represent water molecules. b Schematic diagram of the detailed contacts at the p53 dimer interface. c Key interactions between p53 dimer and BCL-xL. d Schematic diagram of the detailed interactions at the binding interface.