Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 16;7:81. doi: 10.1038/s41420-021-00456-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — A DYRK1A (DYR) expression in U251 cells transfected with doxycycline (DOX)-inducible shRNA targeting DYRK1A (U251 shDYR). Representative images and densitometric quantification of three independent experiments are shown (mean ± SEM, unpaired t-test, *P < 0.05; ***P < 0.001). B Expression of phosphorylated (p-CycD1) and total cyclin D1 (CycD1) in U251 cells treated ± DYRK1A inhibitors L41 and ALGERNON (ALG) for 72 h, and in U251 shDYR cells treated ± DOX. Representative images of two independent experiments are shown. C Design and summary of the proteomic analysis of U251 cells treated ± L41 and ALG for 72 h, and U251 shDYR cells treated ± DOX. D Venn diagram showing overlap among proteins deregulated after DYRK1A pharmacological inhibition (1263 proteins total) and genetic knockdown (220 proteins total).