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. 2021 Apr 17;188:114564. doi: 10.1016/j.bcp.2021.114564

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Fig. 3 — Pelargonidin effect on acute colitis. Colitis was induced by TNBS. After induction of colitis the mice were treated daily with Pelargonidin (5 mg/Kg) or vehicle. Disease was monitored by daily evaluation of (A) changes in body weight (%), (B) colitis disease activity index (CDAI), (C) colon length (cm) and ratio of colon weight/colon length (g/cm). (D) H&E staining of colon sections (10× magnification) and Histological Score from each experimental group. (E) The figure shows immunohistochemistry representative images of the colon of one mouse for each experimental group stained with anti-ACE2 Ab (20x magnification). RNA extracted from colon was used to evaluate, by quantitative real-time PCR, the relative mRNA expression of (F) Ace2, (G) Cyp1a1, (H) Mas, (I) Il-1β, (J) Tnf-α and (K) Tgf-β. Values are normalized relative to Gapdh mRNA. The values are expressed relative to those of control group (NT) which are arbitrarily set to one. Correlation graph of Ace2 mRNA expression and (L) Il-1β (M) Tnf-α. Results are expressed as mean ± SEM (n = 7–12); In graph A * TNBS + Pelargonidin Vs TNBS; in all graphs * p < 0.05.