. 2021 Jan 29;184(4):607–615. doi: 10.1530/EJE-20-1268
This work is licensed under a Table 2.
Classification of HLA genotypes and applied risk class.
| Risk class (this study) | Allele 1 (HLA-DRB1-DQA1-DQB1) | Allele 2 (HLA-DRB1-DQA1-DQB1) | RISK category |
|---|---|---|---|
| 1 | *0301-*0501-*0201 | *0404-*0301-*0302 | Very high |
| 1 | *0404-*0301-*0302 | *0404-*0301-*0302 | High |
| 1 | *0301-*0501-*0201 | *0301-*0501-*0201 | High |
| 2 | *0301-*0501-*0201 | Any other DRB1 allele | Intermediate |
| 3 | *0404-*0301-*0302 | Any other DRB1 allele | Low |
| 3 | Intermediate* | Intermediate * | Low |
| 3 | Intermediate* | Low* | Very low |
| 3 | Low* | Low* | Very low |
* Intermediate: The combination of any of the following HLA-DRB1-DQA1-DQB1 haplotypes: *1401-*0101-*0503, *15-*0102-*0602/*0611, *07-*0201-*0303, *0401-*0301-*0301, *0801-*0401-*04, *11-*0501 -*0301and/or *12-*0501-*0301.
*Low risk: Combination of the HLA-types in the ‘Intermediate risk’ category or the combination of any of the following HLA-DRB1-DQA1-DQB1 haplotypes:*01/*10-*0101-*0501, *1301-*0103-*0603, *1302-*0201-*0604, and/or *07-*0201-*0201.