Table 1.
Characteristics of the patients in Group 1 and Group 2
| Group 1 (n = 44) |
Group 2 (n = 60) |
p | |
|---|---|---|---|
| Age, years | |||
| Mean ± SD | 71.0 ± 8.1 | 74.7 ± 8.0 | 0.024a |
| Gender, n (%) | 0.853b | ||
| Female | 20 (45.5) | 25 (41.7) | |
| Male | 24 (54.5) | 35 (58.3) | |
| Follow-up time, months | |||
| Median (IQR) | 30.50 (47.25) | 27.04 (41.00) | 0.927c |
| BCVA at presentation, logMAR | |||
| Median (IQR) | |||
| Study eye | 0.30 (0.54) | 0.61 (1.08) | 0.023c |
| Fellow-eye | 0.61 (1.75) | 0.40 (1.25) | 0.483c |
| BCVA at V0, logMAR | |||
| Median (IQR) | |||
| Study eye | 0.40 (0.48) | 0.52 (0.70) | 0.031c |
| Fellow-eye | 0.61 (1.36) | 0.52 (1.25) | 0.597c |
| IVI count before V0, n | |||
| Median (IQR) | 10.0 (8.75) | 10.0 (9.00) | 0.974c |
| Planned extension period at V0, weeks | |||
| Median (IQR) | 8.57 (5.96) | 10.0 (5.96) | 0.604c |
| Any accompanying disorders, n (%) | 0.095b | ||
| Present | 19 (43.2) | 37 (61.7) | |
| Absent | 25 (56.8) | 23 (38.3) | |
| Diabetes mellitus, n (%) | 0.971b | ||
| Present | 10 (22.7) | 15 (25.0) | |
| Absent | 34 (77.3) | 45 (75.0) | |
| Hypertension, n (%) | 0.044b | ||
| Present | 16 (36.4) | 35 (58.3) | |
| Absent | 28 (63.6) | 25 (41.7) | |
| Coronary artery disease, n (%) | 0.696d | ||
| Present | 3 (6.8) | 3 (5.0) | |
| Absent | 41 (93.2) | 57 (95.0) |
Statistical significance is highlighted in bold
BCVA best-corrected visual acuity, IVI intravitreal injection, IQR interquartile range, logMAR logarithm of the minimum angle of resolution, SD standard deviation, V0 the last visit before the restriction period where the IVI at restriction period scheduled
aIndependent-samples t test
bPearson Chi-square test with continuity correction
c Mann–Whitney U test
d Fisher’s exact test