Figure 5.

Administration of AR antagonist ameliorates ER stress in PCOS mice. Serum insulin levels (A) and proinsulin levels relative to total insulin (B) in mice of different groups were determined by ELISA. n = 10–12 mice in each group. (C) Insulin and proinsulin levels in islets of mice from different groups were determined by Western blot. n = 6–8 mice in each group. (D) Levels of XBP1(S), CHOP and DR5 mRNA in islets of mice from different groups were measured by real-time PCR and normalized against GAPDH. DHEA, dihydrotestosterone. n = 6–8 mice in each group. Values represent means ± s.d. *P < 0.05, **P < 0.01 compared with control. ^#P < 0.05.